Sequence announces our new website and logo

Read
All Projects

Project Ousia

RNAi Therapeutics, Oligonucleotide Drug Substance

Overview

Alnylam is a biopharmaceutical company developing novel therapeutics based on RNA interference (RNAi). The Alnylam Oligonucleotide Drug Substance Manufacturing Facility in Norton, MA consists of a new 230,000 SF building. The building houses multiproduct, commercial stage biopharmaceutical manufacturing with a sustainable pipeline of RNAi‐based medicines.

Sequence Scope

Manufacturing Train 1

This new facility build-out included the need for C&Q services for the Process Automation System and Building Automation System that collectively monitor and/or control the entire facility. This includes HVAC, clean & dirty utilities for the plant, and manufacturing equipment within the Train 1 suites.

Sequence was responsible for developing functional and design specifications to define general and sequential functionality to automate the processes to produce RNAi (RNA Interference) therapeutics followed by turn-key Automation verification and qualification for all utilities, process equipment, and ancillary equipment on a Rockwell PlantPAX platform.

The effort included development and execution of all life cycle documentation (FATs, IV, OV, IQ, OQ).

The project was completed successfully on time and under budget to allow Alnylam to continue development and manufacturing of life changing RNAi therapeutics.

Life Impact

  • The Alnylam facility develops innovative therapeutics based on RNA interference. RNAi therapeutics developed by Alnylam will target a number of illnesses including TTR, haemophilia, hepatic porphyrias, beta thalassemia, hypertension and liver infections. Products manufactured at the Norton facility are sold across the world. Source

Get Started

How can we support your project success?

Contact Us
855.844.7171 info@sequenceQCS.com
  • Global Headquarters
    2100 Gateway Center Blvd, Suite 301
    Morrisville, NC 27560

  • Lab and Training Center
    2500 Gateway Center Blvd, Suite 850
    Morrisville, NC 27560

  • Northeast Office
    1 Speen Street, Suite 120
    Framingham, MA 01701

Sign up for our email newsletter

Accelerating time to market through proven quality and compliance solutions.

© 2021 Sequence, Inc. All rights reserved.