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Manufacturing Area

Our focus

We’re establishing an understanding of the engineering principles driving the functionality of common systems involved in converting raw materials into finished pharmaceutical products that meet established quality standards.

  • Upstream Processing
  • Cell Culture
  • Growing cells in a single use application to achieve viable cell density requirements
  • DO control, pH control, Temperature control
  • Induction/Infection/Transfection of cells for product generation
  • Harvest filtration principles and control strategies
  • Single use instrumentation and associated control strategies
  • Filter integrity testing principles and execution
  • Viral Inactivation
  • Single use mixer functionality to support reduction of viral load
  • Chromatography
  • Complex flow control to achieve residence time with column resin
  • Sequence of operations to achieve desired purification
  • Utilizing inline UV instrumentation to control product collection
  • Cleaning principles of process piping and resin
  • Ultrafiltration/Diafiltration
  • Complex pressure control to achieve concentration and diafiltration
  • Principles of 100% check weight and application for serialization
  • Achieving sterility in an aseptic environment
  • Supervisory control and data acquisition appropriate for local PLCs
  • Networking principles and communication of non-native devices
  • Centralized and de-centralized I/O networks

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Tulip

No Code App Development for Manufacturing Operations

Tulip creates user-friendly and functional apps that improve the productivity of operations, without writing any code. Users can start from scratch or customize an App Template to fit their needs.

Sequence partners with Tulip for implementation and validation of the Tulip platform as well as creation, configuration and validation of Tulip Applications that are hosted on the platform. Our application builds include Electronic Batch Records, Weigh and Dispense, Digital SOPs for training (with embedded videos) and more.

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